Scientific Research Focusing On Supplements and Health Science

Overview of dietary supplements: 

• Bailey, R. L., Gahche, J. J., Miller, P. E., Thomas, P. R., & Dwyer, J. T. (2013). Why US adults use dietary supplements. JAMA internal medicine, 173(5), 355-361. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1568520

This paper reviews data from the National Health and Nutrition Examination Survey (NHANES) to provide insights into the prevalence of dietary supplement use in the US, reasons why individuals use supplements, and the effectiveness of various supplement types.

1. Protein Powders

• Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., ... & Kreider, R. B. (2018). ISSN exercise & sports nutrition review update: research & recommendations. Journal of the International Society of Sports Nutrition, 15(1), 38. https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0242-y

An extensive review of the current scientific literature relating to exercise and sports nutrition. The review coveres a range of topics, including protein, carbohydrate, and fat intake, as well as supplementation and hydration strategies. 

• Pasiakos, S. M., McLellan, T. M., & Lieberman, H. R. (2015). The effects of protein supplements on muscle mass, strength, and aerobic and anaerobic power in healthy adults: a systematic review. Sports medicine, 45(1), 111-131. https://link.springer.com/article/10.1007%2Fs40279-014-0242-2

An analysis of numerous studies investigating the effects of protein supplementation on various aspects of athletic performance in healthy adults. The authors found that protein supplementation can increase muscle mass and strength when combined with resistance training. However, for individuals new to weight lifting, protein supplementation will likely provide minimal support in building lean muscle mass, but as training volume and intensity increases, the potential effective of protein supplementation increases and may promote muscle hypertrophy.

2. Creatine Monohydrate

• Volek, J. S., Duncan, N. D., Mazzetti, S. A., Staron, R. S., Putukian, M., Gómez, A. L., Pearson, D. R., Fink, W. J., & Kraemer, W. J. (1999). Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Medicine and Science in Sports and Exercise, 31(8), 1147-1156. https://pubmed.ncbi.nlm.nih.gov/10449017/ 

This paper examines the effects of creatine supplementation and heavy resistance training on muscle physiology and athletic performance. The study found that creatine supplementation led to significant increases in strength and muscle mass compared to a placebo group.

• Branch, J. D. (2003). Effect of creatine supplementation on body composition and performance: a meta-analysis. International Journal of Sport Nutrition and Exercise Metabolism, 13(2), 198-226. https://journals.humankinetics.com/view/journals/ijsnem/13/2/article-p198.xml

A comprehensive review investigating the effects of creatine supplementation on body composition and athletic performance. The analysis showed that creatine supplementation led to a significant increase in lean body mass, muscular strength, and power.

3. Ashwagandha

• Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255-262. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/

• Singh, N., Bhalla, M., de Jager, P. and Gilca, M., 2011. An overview on ashwagandha: A rasayana (rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/ 

4. Vitamins

• DeLuca, H. F. (2004). Overview of general physiologic features and functions of vitamin D2,3. The American Journal of Clinical Nutrition, 80(6). https://www.sciencedirect.com/science/article/pii/S0002916522037686?via%3Dihub 

• Jeffrey B. Blumberg PhD, et al., (2018), 'The Use of Multivitamin/Multimineral Supplements: A Modified Delphi Consensus Panel Report'. Clinical Therapeutics, volume 40 issue 4, April 2018, Pages 640- 657 https://www.sciencedirect.com/science/article/pii/S0149291818300894 

5. Weight Loss

• Aaseth, J., Ellefsen, S., Alehagen, U., Sundfør, T.M., & Alexander, J. (2021). Diets and drugs for weight loss and health in obesity – An update. Biomedicine & Pharmacotherapy, 140, 111789. https://www.sciencedirect.com/science/article/pii/S0753332221005710 

6. Fenugreek

• Neelakantan, N., Narayanan, M., de Souza, R. J., van Dam, R. M., & Matthews, D. R. (2014). Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutrition Journal, 13(1), 7. https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-7

• Steels, E., Rao, A., & Vitetta, L. (2011). Physiological aspects of male libido enhanced by standardized Trigonella foenum‐graecum extract and mineral formulation. Phytotherapy Research, 25(9), 1294-1300. https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.3360

7. Testosterone Boosters

• Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Mac, R. P., Lee, M., ... & Storer, T. W. (2001). Testosterone dose-response relationships in healthy young men. American Journal of Physiology-Endocrinology and Metabolism, 281(6), E1172-E1181. https://journals.physiology.org/doi/full/10.1152/ajpendo.2001.281.6.E1172

8. Collagen

• Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., ... & Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current medical research and opinion, 24(5), 1485-1496. https://www.tandfonline.com/doi/abs/10.1185/030079908X291967

• Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of cosmetic dermatology, 14(4), 291-301. https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12174

9. Biotin

• Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303-305. https://europepmc.org/article/med/8477615

• Zempleni, J., Hassan, Y. I., & Wijeratne, S. S. (2008). Biotin and biotinidase deficiency. Expert Review of Endocrinology & Metabolism, 3(6), 715-724. https://www.tandfonline.com/doi/abs/10.1586/17446651.3.6.715

10. Turmeric

• Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A review of its' effects on human health. Foods, 6(10), 92. https://www.mdpi.com/2304-8158/6/10/92

• Daily, J. W., Yang, M., & Park, S. (2016). Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta-analysis of randomized clinical trials. Journal of medicinal food, 19(8), 717-729. https://www.liebertpub.com/doi/abs/10.1089/jmf.2016.3705

11. Brain and Studying

• Gómez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci. 2008 Jul;9(7):568-78. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805706/ 

12. Dietary Minerals

• Tako, E., 2019. Dietary Trace Minerals. Nutrients, 11(11). 2823. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893782/ 

13. Insomnia

• Lemoine, P., Nir, T., Laudon, M., & Zisapel, N. (2007). Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. Journal of sleep research, 16(4), 372-380. 
• https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2869.2007.00613.x

14. Immune Support

• Hemilä, H., & Chalker, E. (2013). Vitamin C for preventing and treating the common cold. The Cochrane database of systematic reviews, 1(1), CD000980. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000980.pub4/full

15. BCAA's

• Howatson, G., Hoad, M., Goodall, S., Tallent, J., Bell, P. G., & French, D. N. (2012). Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomised, double-blind, placebo controlled study. Journal of the International Society of Sports Nutrition, 9(1), 20. https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-20

• Ispoglou, T., King, R. F., Polman, R. C., & Zanker, C. (2011). Daily L-leucine supplementation in novice trainees during a 12-week weight training program. International journal of sports physiology and performance, 6(1), 38-50. https://journals.humankinetics.com/view/journals/ijspp/6/1/article-p38.xml

16. Skin Health

• Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomised, placebo-controlled clinical trials. Journal of cosmetic dermatology, 14(4), 291-301. https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12174

• Hester, S., Wood, S., Gray, R., Kern, D., & Draelos, Z. (2021). Collagen Supplement Improves Skin Attributes in Healthy Adults. Current Developments in Nutrition, 5(Supplement 2), 321. https://www.sciencedirect.com/science/article/pii/S2475299123108390

17. Fibre

• Dhingra, D., Michael, M., Rajput, H., & Patil, R.T. (2012). Dietary fibre in foods: a review. Journal of Food Science and Technology, 49(3), 255-266. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614039/

18. Joint Support

• Aghamohammadi, D., Dolatkhah, N., Bakhtiari, F., Eslamian, F., & Hashemian, M. (2020). Nutraceutical supplements in management of pain and disability in osteoarthritis: a systematic review and meta-analysis of randomized clinical trials. Scientific Reports, 10(1), https://www.nature.com/articles/s41598-020-78075-x 

19. Digestive Enzymes

• Alyson Powell Key, (2021), 'What Are Digestive Enzymes?', Nourish By WebMD, https://www.webmd.com/diet/what-are-digestive-enzymes 

20. Turkesterone

• Syrov, V. N., Kurmukov, A. G., & Sakhibov, A. D. (1978). [Effect of turkesterone and nerobol on the activity of the protein synthesizing system of mouse liver], Voprosy Meditsinskoi Khimii, 24(4), 456-460. https://europepmc.org/article/med/685188

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The scientific articles referenced on this page are provided for informational purposes only. The views, opinions, and conclusions expressed in these articles are those of the authors and do not necessarily reflect the views of Everything Supplements. Everything Supplements does not claim ownership or authorship of these articles and is not responsible for any errors or omissions in them. The use of these articles is at your own risk, and you should always consult a qualified professional before making any health decisions based on the information presented here.